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Hum. Reprod. Advance Access originally published online on August 6, 2004
Human Reproduction 2004 19(11):2465-2473; doi:10.1093/humrep/deh458
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Human Reproduction vol. 19 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1{beta} and hCG in human endometrial cells

Jihong Kang1, Ali Akoum3,4, Pierre Chapdelaine1, Philippe Laberge1,4, Patrice E. Poubelle2 and Michel A. Fortier1,4,5

Unité de Recherche en 1Ontogénie et Reproduction et 2 Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL, 2705 Boul. Laurier, Ste-Foy, Québec, G1V 4G2, 3 Endocrinologie de la Reproduction Centre de Recherche de l'Hôpital St-François d'Assise and 4 Département d'Obstétrique et Gynécologie, Université Laval, Ste-Foy, Québec, G1K 7P4, Canada

5 To whom correspondence should be addressed at: Unité de Recherche en Ontogénie et Reproduction, Centre Hospitalier Universitaire de Québec (CHUL), Université Laval, 2705, Boul. Laurier, Sainte-Foy, Québec, G1V 4G2, Canada. Email: mafortier{at}crchul.ulaval.ca

BACKGROUND: Inflammatory mediators such as prostaglandins (PG), chemokines, cytokines and their interactions regulate reproductive functions. The relationship between PG and monocyte chemoattractant protein-1 (MCP-1) has not been elucidated in human endometrium. The presence of hCG receptors in the human endometrium suggests that this embryonic signal may exert a local function in this tissue. Our objectives were to investigate the possible association between PG and MCP-1 and to examine the role of hCG in interleukin-1{beta} (IL-1{beta})-regulated PG and MCP-1 production in human endometrium. METHODS: Primary cell cultures isolated from endometrial biopsies were used as an in vitro model. PG and MCP-1 levels were measured in the culture medium. RESULTS: IL-1{beta} stimulates the production of both PG and MCP-1. Neither COX inhibitors nor direct addition of PG affects MCP-1 production. By contrast, MCP-1 is able to induce PGE2 and PGF2{alpha} in a concentration-dependent manner but it does not appear to contribute to the increase in PG accumulation following IL-1{beta} stimulation. hCG inhibits IL-1{beta}-induced PG level. However, hCG has no effect on either basal or IL-1{beta}-mediated MCP-1 level. CONCLUSIONS: PG are not involved in the regulation of MCP-1 production in endometrial cells. hCG appears to play a local function in the endometrium.

Key words: hCG/human endometrium/IL-1{beta}/MCP-1/prostaglandins


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