Skip Navigation


Hum. Reprod. Advance Access originally published online on September 23, 2004
Human Reproduction 2004 19(11):2484-2489; doi:10.1093/humrep/deh448
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
19/11/2484    most recent
deh448v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tufan, E.
Right arrow Articles by Durmusoglu, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tufan, E.
Right arrow Articles by Durmusoglu, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction vol. 19 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Assessment of reproductive ageing patterns by hormonal and ultrasonographic ovarian reserve tests

E. Tufan1, K. Elter1,2 and F. Durmusoglu1

1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Marmara University School of Medicine, Istanbul, Turkey

2 To whom correspondence should be addressed at: Kuyubasi S.Fenik Apt. No: 20/17, 34724 Feneryolu, Istanbul, Turkey. Email: korayelter{at}marmara.edu.tr

BACKGROUND: Tests to assess the change in ovarian reserve (OR) with age have been analysed only in monophasic or biphasic linear patterns. Our aim was to analyse an optimum curve that might define the relationship between different OR tests and age. METHODS: A total of 81 regularly menstruating women without a history of infertility were included in this prospective study. On cycle day 3, antral follicle (AF) counts, ovarian volume (OV), and serum FSH and estradiol levels were determined. Curve estimation was performed to determine the optimal relationship between age and OR tests. Optimum curves were also compared with monophasic and biphasic linear relationships. RESULTS: A quadratic model (y=axx2+bxx+c) had the highest coefficient of determination for the AF count, OV and serum FSH level. The predictive power of this quadratic model was comparable with biphasic linear models for the OV and serum FSH level, but was better than that of the AF count. CONCLUSIONS: The pattern of reproductive ageing as assessed by hormonal and ultrasonographic OR tests does not appear to show an abrupt change at a certain age, but follows a continuously increasing rate of decline in the third decade of life. The changes in serum FSH levels and ultrasonographic OR tests follow a quadratic model in regularly menstruating women.

Key words: age/antral follicle/FSH/ovarian reserve/ovarian volume


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
Y.A. Wang, D. Healy, D. Black, and E.A. Sullivan
Age-specific success rate for women undertaking their first assisted reproduction technology treatment using their own oocytes in Australia, 2002-2005
Hum. Reprod., July 1, 2008; 23(7): 1633 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.L. Haadsma, A. Bukman, H. Groen, E.M.A. Roeloffzen, E.R. Groenewoud, M.J. Heineman, and A. Hoek
The number of small antral follicles (2-6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population
Hum. Reprod., July 1, 2007; 22(7): 1925 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
JJ. Ireland, F. Ward, F. Jimenez-Krassel, J.L.H. Ireland, G.W. Smith, P. Lonergan, and A.C.O. Evans
Follicle numbers are highly repeatable within individual animals but are inversely correlated with FSH concentrations and the proportion of good-quality embryos after ovarian stimulation in cattle
Hum. Reprod., June 1, 2007; 22(6): 1687 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. I. Leibel, E. E. Baumann, M. Kocherginsky, and R. L. Rosenfield
Relationship of Adolescent Polycystic Ovary Syndrome to Parental Metabolic Syndrome
J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1275 - 1283.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.