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Hum. Reprod. Advance Access originally published online on August 19, 2004
Human Reproduction 2004 19(11):2674-2679; doi:10.1093/humrep/deh494
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Human Reproduction vol. 19 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Follicular growth during contraceptive pill or vaginal ring treatment depends on the day of ovulation in the pretreatment cycle

Ingrid J.M. Duijkers1,3, Carole H.J. Verhoeven2, Thom O.M. Dieben2 and Christine Klipping1

1 Dinox Medical Investigations, Groenewoudseweg 317, 6524 TX Nijmegen and 2 NV Organon, P.O.Box 20, 5340 BH Oss, The Netherlands

3 To whom correspondence should be addressed. Email: iduijkers{at}dinoxgroup.com

BACKGROUND: The aim of this study was to investigate whether the day of ovulation and the duration of a pretreatment cycle were related to the degree of follicular growth during subsequent contraceptive treatment. METHODS: This randomized, open-label study was performed in 40 healthy female volunteers, who were randomized by a computer-generated list after stratification for the ovulation day in a pretreatment cycle. They received two cycles of NuvaRing (21 subjects) or a combined oral contraceptive (COC) containing 30 µg ethinylestradiol and 150 µg levonorgestrel (19 subjects). Follicular diameter and serum hormone concentrations (FSH, LH, 17{beta}-estradiol, progesterone) were measured every third day. Data from treatment day 20 onwards were used for analysis. RESULTS: In the NuvaRing users, subjects with short cycles and early ovulations in the pretreatment cycle developed larger follicles during treatment than subjects with longer cycles and late ovulations. In the COC users, subjects with early ovulations in the pretreatment cycle developed larger follicles during treatment. CONCLUSIONS: The degree of follicular growth during treatment with a combined hormonal contraceptive is influenced by the duration of the pretreatment cycle and particularly by the duration of the follicular phase.

Key words: follicular growth/oral contraceptive/pill-free interval/vaginal ring


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