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Human Reproduction, Vol. 19, No. 2, 357-359, February 2004
© 2004 European Society of Human Reproduction and Embryology

C-reactive protein levels in patients undergoing controlled ovarian hyperstimulation for IVF cycle

Raoul Orvieto1, Roni Chen, Jacob Ashkenazi, Avi Ben-Harush, Jacob Bar and Benjamin Fisch

Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva 49 100, Israel. e-mail: orvieto{at}clalit.org.il

BACKGROUND: The aim of the present study was to determine serum and follicular fluid C-reactive protein (CRP) levels in patients undergoing controlled ovarian hyperstimulation (COH) for IVF-embryo transfer cycle, and their possible correlation to COH variables. PATIENTS AND METHODS: The subjects were 16 consecutive patients undergoing our routine IVF long GnRH agonist protocol. Blood was drawn three times during the COH cycle: (i) the day on which adequate suppression was obtained (Day-S); (ii) the day of, or prior to HCG administration (Day-HCG); and (iii) the day of (and before) oocyte pick-up (Day-OPU). Levels of sex steroids and serum and follicular fluid CRP were compared among the three time points. Serum and follicular fluid CRP were measured with a commercial immunoturbidimetric assay. RESULTS: Serum levels of CRP were significantly higher on Day-OPU and Day-HCG than on Day-S, and significantly higher on Day-OPU than on Day-HCG. No difference was observed between follicular and serum CRP levels on Day-OPU. No significant correlations were found between serum and follicular fluid CRP, or between serum CRP-to-BMI ratio and serum sex steroid levels or IVF treatment variables. CONCLUSIONS: The significant increase in serum CRP levels during COH, especially after HCG administration, suggests that COH potentiates a state of systemic inflammation.

Key words: BMI/C-reactive protein/follicular fluid/ovulation induction/sex steroids


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