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Human Reproduction, Vol. 19, No. 2, 371-377, February 2004
© 2004 European Society of Human Reproduction and Embryology

The Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ): a validation

G.L. Jones1,5, K. Benes2, T.L. Clark2, R. Denham2, M.G. Holder2, T.J. Haynes2, N.C. Mulgrew2, K.E. Shepherd2, V.H. Wilkinson2, M. Singh3, A. Balen3, H. Lashen4 and W.L. Ledger4

1 University of Sheffield Institute of General Practice and Primary Care, Community Sciences Building, Herries Rd, Northern General Hospital, Sheffield S5 7AU, 2 University of Sheffield School of Medicine and Biomedical Sciences, Beech Hill Rd, Sheffield S10 2RX, 3 The General Infirmary at Leeds, Clarendon Wing, Belmont Grove, Leeds LS2 9NS and 4 University of Sheffield Academic Unit of Reproductive and Developmental Medicine, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK 5 To whom all correspondence should be addressed. e-mail: G.L.Jones{at}sheffield.ac.uk

BACKGROUND: We wished to evaluate the psychometric properties of the Polycystic Ovary Syndrome Questionnaire (PCOSQ), a questionnaire developed to measure the health-related quality of life (HRQoL) of women with polycystic ovary syndrome. METHOD: To assess reliability and validity, women recruited from an outpatient gynaecology clinic at the Jessop Wing, Royal Hallamshire Hospital, Sheffield completed two copies of the PCOSQ and the Short Form-36 (SF-36). Secondary factor analysis was carried out to verify the composition of the dimensions. Semi-structured interviews were conducted to assess face validity. RESULTS: Of the 92 women who consented, 82 women (89%) returned questionnaires at time 1, and 69 women (75%) returned questionnaires at time 2. All five PCOSQ dimensions were internally reliable with Cronbach’s {alpha} scores ranging from 0.70 to 0.97. Intra-class correlation coefficients to evaluate test–retest reliability were high (range 0.89–0.95, P < 0.001). Construct validity was demonstrated by high correlations for all comparisons of similar scales of the SF-36 and PCOSQ (0.49 and 0.54). Acne was identified as an important area of HRQoL missing from the questionnaire. CONCLUSIONS: The PCOSQ is a reliable instrument for measuring the HRQoL in women with PCOS. However, the validity of the questionnaire needs to be improved by incorporating a dimension on acne into the instrument.

Key words: health-related quality of life/health status/polycystic ovary syndrome/psychometric properties/questionnaires


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