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Hum. Reprod. Advance Access originally published online on January 29, 2004
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Human Reproduction, Vol. 19, No. 3, 467-469, March 2004
© 2004 European Society of Human Reproduction and Embryology

Assessment of ovarian reserve

Is there still a role for ovarian biopsy in the light of new data?

Amir Lass

Serono Ltd, Bedfont Cross, Stanwell Road, Middlesex TW14 8NX, UK e-mail: amir.lass{at}serono.com

Ovarian reserve depends on the number of primordial follicles in the ovarian cortex. It was suggested that determining the follicular density directly by obtaining ovarian biopsy might be more accurate than current indirect biochemical and ultrasonic tests, especially for women in the later stage of their reproductive life. It might also be important and beneficial for young patients having chemotherapy for malignant disease in whom the ovarian tissue should be considered for reimplantation after recovery. The advantages and pitfalls of obtaining ovarian biopsy in these cases are discussed in light of new emerging data on the natural distribution of primordial follicles in the human ovary and its implications.

Key words: cancer/ovarian biopsy/ovarian reserve/primordial follicles


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