Hum. Reprod. Advance Access originally published online on January 29, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human Reproduction, Vol. 19, No. 3, 477-480,
March 2004
© 2004 European Society of Human Reproduction and Embryology
Ovarian tissue banking for cancer patients
Fertility preservation, not just ovarian cryopreservation
1 The Center for Reproductive Medicine and Infertility, Joan and Sanford I.Weill Medical College of Cornell University, 505 East 70th Street, HT-340, New York, NY 10021, USA
2 To whom correspondence should be addressed. e-mail: kuo9001{at}med.cornell.edu
While ovarian tissue cryopreservation has commonly been equated with fertility preservation in cancer patients, there is a range of alternative options to preserve fertility. Based on the type and timing of chemotherapy, the type of cancer, the patient’s age and the partner status, a different strategy of fertility preservation may be needed. If the patient has a partner or accepts donor sperm, embryo cryopreservation should be considered first, since this is a clinically well established procedure. Despite relatively low pregnancy rates, when there is time for ovarian stimulation and the patient is single, oocyte cryopreservation may also be preferred to ovarian tissue banking. In breast cancer patients, tamoxifen or aromatase inhibitors can be used for ovarian stimulation prior to oocyte or embryo cryopreservation. In endometrial cancer patients, aromatase inhibitors may be the only choice for ovarian stimulation. When only pelvic radiotherapy is used, ovarian transposition can be performed, but the success rates vary because of scatter radiation and vascular compromise. Lack of FSH and GnRH receptors on primordial follicles and oocytes does not make gonadal suppression an effective strategy of gonadal protection. Fertility preservation should be an integral part of improving the quality of life in cancer survivors; however, it is neither possible nor ethical to recommend the same recipe for every cancer patient.
Key words: cancer/cryopreservation/fertility preservation/ovarian transplantation/ovulation induction
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Demeestere, P. Simon, S. Emiliani, A. Delbaere, and Y. Englert Orthotopic and heterotopic ovarian tissue transplantation Hum. Reprod. Update, November 1, 2009; 15(6): 649 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Beck-Fruchter, A. Weiss, and E. Shalev GnRH agonist therapy as ovarian protectants in female patients undergoing chemotherapy: a review of the clinical data Hum. Reprod. Update, November 1, 2008; 14(6): 553 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rice, K. Ojha, and H. Mason Human ovarian biopsies as a viable source of pre-antral follicles Hum. Reprod., March 1, 2008; 23(3): 600 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Vadaparampil, H. Clayton, G. P. Quinn, L. M. King, M. Nieder, and C. Wilson Pediatric Oncology Nurses' Attitudes Related to Discussing Fertility Preservation With Pediatric Cancer Patients and Their Families Journal of Pediatric Oncology Nursing, October 1, 2007; 24(5): 255 - 263. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Oktay, M. Sonmezer, O. Oktem, K. Fox, G. Emons, and H. Bang Absence of Conclusive Evidence for the Safety and Efficacy of Gonadotropin-Releasing Hormone Analogue Treatment in Protecting Against Chemotherapy-Induced Gonadal Injury Oncologist, September 1, 2007; 12(9): 1055 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Soleimani, W. De Vos, P. Van Oostveldt, S. Lierman, R Van den Broecke, P. De Sutter, M. Dhont, and J. Van der Elst Two novel techniques to detect follicles in human ovarian cortical tissue Hum. Reprod., July 1, 2006; 21(7): 1720 - 1724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Knobf The influence of endocrine effects of adjuvant therapy on quality of life outcomes in younger breast cancer survivors. Oncologist, February 1, 2006; 11(2): 96 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bordes, J. Lornage, B. Demirci, M. Franck, B. Courbiere, J. F. Guerin, and B. Salle Normal gestations and live births after orthotopic autograft of vitrified-warmed hemi-ovaries into ewes Hum. Reprod., October 1, 2005; 20(10): 2745 - 2748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Oehninger Strategies for Fertility Preservation in Female and Male Cancer Survivors Reproductive Sciences, May 1, 2005; 12(4): 222 - 231. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Sklar Maintenance of Ovarian Function and Risk of Premature Menopause Related to Cancer Treatment J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 25 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Robertson Cancer and Fertility: Ethical and Legal Challenges J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 104 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Patrizio, S. Butts, and A. Caplan Ovarian Tissue Preservation and Future Fertility: Emerging Technologies and Ethical Considerations J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 107 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Blumenfeld Ovarian cryopreservation versus ovarian suppression by GnRH analogues: primum non nocere Hum. Reprod., August 1, 2004; 19(8): 1924 - 1925. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Bedaiwy and T. Falcone Ovarian tissue banking for cancer patients: Reduction of post-transplantation ischaemic injury: intact ovary freezing and transplantation Hum. Reprod., June 1, 2004; 19(6): 1242 - 1244. [Abstract] [Full Text] [PDF]
|
|