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Hum. Reprod. Advance Access originally published online on May 13, 2004
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Human Reproduction, Vol. 19, No. 7, 1598-1603, July 2004
© 2004 European Society of Human Reproduction and Embryology

A prospective, randomized study: day 3 versus hatching blastocyst stage

Takafumi Utsunomiya1,3, Hiroko Ito2, Miyuki Nagaki1 and Junko Sato1

1 St Luke Clinic, 5, Tsumori-Tomioka, Oita City 870-0947 and 2 Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 Idaigaoka, Hasamacho, 879-5593, Oita Prefecture, Japan

3 To whom correspondence should be addressed. e-mail: st-luke{at}oct-net.ne.jp

BACKGROUND: Recently, advances in human IVF-embryo transfer (ET) have been reported using sequential media and blastocyst stage ET. In our previous report, using a prospective, randomized study, no advantage was found using the blastocyst stage ET compared with day 3 ET. This study was performed in order to evaluate implantation and pregnancy rates of hatching blastocyst stage ET compared with conventional day 3 ET. METHODS AND RESULTS: A total of 480 patient cycles were evaluated using a prospective, randomized study. The pregnancy rate and implantation rate were compared between the day 3 ET (n = 240) and hatching blastocyst stage ET (Hat ET; n = 240). The Hat ET group had a pregnancy rate of 29.3% (55 out of 188) and an implantation rate of 21.4% (67 out of 313). The day 3 ET group had a pregnancy rate of 29.2% (70 out of 240) and an implantation rate of 19.1% (93 out of 488). In the Hat ET group, the pregnancy rate, implantation rate and ongoing pregnancy rate of day 5 ET and day 6 ET were all higher than the respective rates in the day 7–9 ET group. CONCLUSION: We found that the pregnancy rate and implantation rate of ET with hatching stage blastocysts had no advantage compared with the conventional day 3 ET.

Key words: blastocyst culture/embryo transfer/hatching stage/pregnancy rate


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