Hum. Reprod. Advance Access originally published online on May 27, 2004
Human Reproduction 2004 19(8):1741-1745; doi:10.1093/humrep/deh319
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An economic comparison of a laparoscopic electrocautery strategy and ovulation induction with recombinant FSH in women with clomiphene citrate-resistant polycystic ovary syndrome
1 Center for Reproductive Medicine, Department of Obstetrics and Gynaecology (H4-205), and 2 Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, P.O.Box 22700, 1100 DE Amsterdam, The Netherlands
3 To whom correspondence should be addressed. Email: m.vanwely{at}amc.uva.nl
BACKGROUND: Recombinant FSH (rFSH) is the current standard treatment for ovulation induction in women with polycystic ovary syndrome (PCOS) that do not respond to clomiphene citrate. Ovulation induction with rFSH is known to be costly due to the necessity of daily injections and intensive monitoring. An alternative strategy, starting with electrocautery of the ovaries, may be a less costly option. METHODS: An economic evaluation was set up alongside a multicentre randomized clinical trial comparing laparoscopic electrocautery of the ovaries, followed by clomiphene citrate and rFSH when anovulation persisted, and treatment with rFSH in 168 women with clomiphene citrate-resistant PCOS. Data on resources used for treatment and productivity loss were collected prospectively up to an eventual ongoing pregnancy with a time horizon of 12 months. RESULTS: At 12 months the ongoing pregnancy rates were 67% for both the electrocautery strategy and rFSH treatment. Mean total costs per woman were 
5308 for the electrocautery strategy and 5925 for treatment with rFSH, resulting in a mean difference of 617 (95% CI: –382 to 1614). CONCLUSIONS: The total treatment costs up to an ongoing pregnancy are comparable for rFSH treatment and an alternative strategy starting with electrocautery. Due to a lower number of multiple pregnancies, the electrocautery strategy can be expected to result in lower total costs when costs of the delivery are included.
Key words: cost minimization/gonadotrophin/laparoscopic electrocautery/ovulation induction/PCOS
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