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Hum. Reprod. Advance Access originally published online on October 28, 2004
Human Reproduction 2005 20(1):147-148; doi:10.1093/humrep/deh587
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Human Reproduction vol. 20 no. 1 © European Society of Human Reproduction and Embryology 2004; all rights reserved

A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: Case report

Nobuo Sugawara1,4, Yo Tokunaga2, Machiko Maeda1, Rie Komaba1 and Yasuhisa Araki3

1 Iwaki Women's Clinic, 3-2, Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, 2 Iwakisaiseikai Foundation Matsumura General Hospital, 1-1, Tairakotaro, Iwaki, Fukushima, 970-8516 and 3 The Institute for ARMT, 909-21, Ishii, Fujimi, Setagun, Gunma, 371-0105, Japan

4 To whom correspondence should be addressed at: Iwaki Women's Clinic, 3-2, Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan. Email: sugawara{at}iwaki-fu.or.jp

BACKGROUND: We report a very rare case of the successful delivery of a healthy infant fathered by an infertile chimera. METHODS: ICSI was performed using frozen sperm. The karyotypes of peripheral lymphocytes were examined with a G-banding stain. RESULTS: Chromosomal analysis prior to ICSI revealed a 46, XX [28]/46, XY [2] karyotype chimera. As an infant, the subject was diagnosed as a true hermaphrodite, and underwent a hysterectomy and oophorectomy. A small number of sperm were found in minced testicular tissue, and they were stored for ICSI. CONCLUSION: To the best of our knowledge, this is the first case report of a successful pregnancy and delivery of a healthy infant fathered by an infertile chimera (46, XX/46, XY) following ICSI using frozen testicular sperm.

Key words: azoospermia/chimera/hermaphrodite/ICSI/XX/XY


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