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Hum. Reprod. Advance Access originally published online on January 7, 2005
Human Reproduction 2005 20(4):986-990; doi:10.1093/humrep/deh710
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Serological markers of persistent C. trachomatis infections in women with tubal factor subfertility

J.E. den Hartog1,4, J.A. Land1, F.R.M. Stassen2, A.G.H. Kessels3 and C.A. Bruggeman2

1 Research Institute Growth and Development (GROW) and Department of Obstetrics and Gynaecology, 2 Maastricht Infection Centre (MINC) and Department of Medical Microbiology and 3 Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Academisch Ziekenhuis Maastricht, P.O.Box 5800, 6202 AZ Maastricht, The Netherlands

4 To whom correspondence should be addressed. Email: jedh{at}sgyn.azm.nl

BACKGROUND: Persistent C. trachomatis infections are assumed to increase the risk of tubal pathology. We studied whether serological markers, assumed to be associated with persistent C. trachomatis infections, could identify subfertile women at risk of tubal pathology. METHODS: Sera of 313 subfertile women, who all underwent a laparoscopy with tubal testing to assess the grade of tubal pathology, were tested for the presence of immunoglobulin (Ig) G and IgA antibodies to C. trachomatis, IgG antibodies to chlamydia heat shock protein 60 (cHSP60) and C-reactive protein (CRP). RESULTS: C. trachomatis IgA, cHSP60 IgG and CRP, all serological markers of persistent infections, were significantly more prevalent in women with tubal pathology as compared to those without tubal pathology. The predictive value of the currently used screening test for tubal pathology (IgG to C. trachomatis) could be significantly improved by adding the CRP test. CONCLUSIONS: In subfertile women with tubal pathology, serological markers of persistent C. trachomatis infections are significantly more common as compared to women without tubal pathology. C. trachomatis IgG-positive subfertile women with slightly elevated (<10 mg/l) CRP levels are at highest risk of persistent C. trachomatis infections and tubal pathology.

Key words: Chlamydia trachomatis/chlamydia heat shock protein 60/C-reactive protein/immunoglobulin A/persistent infection


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