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Hum. Reprod. Advance Access originally published online on December 23, 2004
Human Reproduction 2005 20(4):997-998; doi:10.1093/humrep/deh707
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© The Author 2004. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: Case report

Antonio Scotto di Frega1, Brian Dale1, Loredana Di Matteo1,2 and Martin Wilding1,3

1 Centre for Reproductive Biology, Clinica Villa del Sole, Via Manzoni, 15 and 2 Facolta di Medicina e Chirurgia, II Università degli Studi di Napoli, Via Costantinopoli, 16, 80126 Naples, Italy

3 To whom correspondence should be addressed. Email: martinwilding{at}hotmail.com

Surgical treatments such as the Roux-en-Y gastric bypass operation result in the successful treatment of morbid obesity; however, this type of operation may cause long-term side effects due to the reduced absorption of nutrients. Here, we present data suggesting that this operation can result in secondary infertility in males. Six healthy, previously fertile male subjects presented in our centre for secondary infertility after a Roux-en-Y gastric bypass operation for morbid obesity. Reproductive function was assessed with a series of spermiograms, and by testicular biopsy. Secondary azoospermy with complete spermatogenic arrest was diagnosed. The results suggest that weight reduction surgery may cause reproductive dysfunction.

Key words: male factor infertility/obesity/Roux-en-Y gastric bypass/spermatogenesis


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