Hum. Reprod. Advance Access originally published online on February 3, 2005
Human Reproduction 2005 20(5):1418-1421; doi:10.1093/humrep/deh764
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Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: results of the German IGLU Follow-up Study 2001
1 University Hospital for Children and Adolescents, Erlangen, 2 Paediatric Endocrinology Section, University Children's Hospital, Tübingen, 3 University Children's Hospital, Heidelberg, 4 Department of Paediatric Haematology/Oncology and Endocrinology, University Children's Hospital, Essen, 5 University Children's Hospital, Munich, 6 Paediatric Endocrinology, University Children's Hospital, Kiel and 7 Pfizer Corporation, Karlsruhe, 8 University Children's Hospital, Hamburg, Germany
9 To whom correspondence should be addressed at: Paediatric Endocrinology, University Hospital for Children and Adolescents, Loschgestr.15, D-91054 Erlangen, Germany. Email: hgdoerr{at}kinder.imed.uni-erlangen.de
BACKGROUND: To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment. METHODS: Cross-sectional study. Out of 188 women with TS from 96 German centres, whose longitudinal growth was documented within KIGS (Pfizer International Growth Database), data on uterine size were collected voluntarily at a standardized follow-up visit: 75 TS women (ages: 15.8–30.8 years) with complete data were included. Classification according to karyotype: 45,X (78.6%), 45,X/46,XX (5.4%), 45,X/46,iXq (8%), 45,X/46,XY (8%). Puberty was induced with estrogens in all women. At follow-up, 66 were on cyclic estrogens and progestins. RESULTS: 13/66 (19.6%) TS women who received estrogens had a reduced uterine length <5 cm. Calculating the data in standard deviation scores (SDS), only women with 45,X/46,XX karyotype had normal median uterine length and volume of 0.6 and 1.59 SDS respectively. An incomplete breast development (Tanner stage B 3) was found in women with 45,X karyotype (n=11; 18.6%) and with 45,X/46,XY (n=2). CONCLUSIONS: Only TS women with karyotype 45,X/46,XX had normal uterine sizes, whereas 26% of the TS women with karyotype 45,X had a uterine length <–2 SDS, and 18% a volume <–2 SDS.
Key words: estrogen therapy/gonadal dysgenesis/Turner syndrome/uterine size
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