Skip Navigation


Hum. Reprod. Advance Access originally published online on March 10, 2005
Human Reproduction 2005 20(6):1636-1641; doi:10.1093/humrep/deh821
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/6/1636    most recent
deh821v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hunault, C. C.
Right arrow Articles by Habbema, J. D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hunault, C. C.
Right arrow Articles by Habbema, J. D. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Prospective validation of two models predicting pregnancy leading to live birth among untreated subfertile couples

Claudine C. Hunault1,4, Joop S.E. Laven2, Ilse A.J. van Rooij3, Marinus J.C. Eijkemans1, Egbert R. te Velde3 and J. Dik F. Habbema1

1 Department of Public Health and 2 Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Erasmus MC University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam and 3 Department of Reproductive Medicine, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

4 To whom correspondence should be addressed. Email: c.hunault{at}erasmusmc.nl

BACKGROUND: Models predicting clinical outcome need external validation before they can be applied safely in daily practice. This study aimed to validate two models for the prediction of the chance of treatment-independent pregnancy leading to live birth among subfertile couples. METHODS: The first model uses the woman's age, duration and type of subfertility, percentage of progressive sperm motility and referral status. The second model in addition uses the result of the post-coital test (PCT). For validation, these characteristics were collected prospectively in two University hospitals for 302 couples consulting for subfertility. The models' ability to distinguish between women who became pregnant and women who did not (discrimination) and the agreement between predicted and observed probabilities of treatment-independent pregnancy (calibration) were assessed. RESULTS: The discrimination of both models was slightly lower in the validation sample than in the original sample which provided the model. Calibration was good: the observed and predicted probabilities of treatment-independent pregnancy leading to live birth did not differ for both models. CONCLUSIONS: The chance of pregnancy leading to live birth was reliably estimated in the validation sample by both models. The use of PCT improved the discrimination of the models. These models can be useful in counselling subfertile couples.

Key words: PCT/prediction model/subfertility/treatment-independent pregnancy/validation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
M. Brandes, C.J.C.M. Hamilton, J.P. de Bruin, W.L.D.M. Nelen, and J.A.M. Kremer
The relative contribution of IVF to the total ongoing pregnancy rate in a subfertile cohort
Hum. Reprod., October 24, 2009; (2009) dep341v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
E. Leushuis, J. W. van der Steeg, P. Steures, P. M.M. Bossuyt, M. J.C. Eijkemans, F. van der Veen, B. W.J. Mol, and P. G.A. Hompes
Prediction models in reproductive medicine: a critical appraisal
Hum. Reprod. Update, September 1, 2009; 15(5): 537 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S.F.P.J. Coppus, F. van der Veen, B.C. Opmeer, B.W.J. Mol, and P.M.M. Bossuyt
Evaluating prediction models in reproductive medicine
Hum. Reprod., August 1, 2009; 24(8): 1774 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
P. Devroey, B.C.J.M. Fauser, K. Diedrich, and on behalf of the Evian Annual Reproduction (EVAR)
Approaches to improve the diagnosis and management of infertility
Hum. Reprod. Update, July 1, 2009; 15(4): 391 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. L. Tollner, A. I. Yudin, C. A. Treece, J. W. Overstreet, and G. N. Cherr
Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus
Hum. Reprod., November 1, 2008; 23(11): 2523 - 2534.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.L. Haadsma, H. Groen, V. Fidler, A. Bukman, E.M.A. Roeloffzen, E.R. Groenewoud, F.J.M. Broekmans, M.J. Heineman, and A. Hoek
The predictive value of ovarian reserve tests for spontaneous pregnancy in subfertile ovulatory women
Hum. Reprod., August 1, 2008; 23(8): 1800 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
F.J. Broekmans, J. Kwee, D.J. Hendriks, B.W. Mol, and C.B. Lambalk
A systematic review of tests predicting ovarian reserve and IVF outcome
Hum. Reprod. Update, November 1, 2006; 12(6): 685 - 718.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.