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Hum. Reprod. Advance Access originally published online on March 24, 2005
Human Reproduction 2005 20(6):1642-1646; doi:10.1093/humrep/deh807
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Comparison of outcome of pregnancy after intra-uterine insemination (IUI) and IVF

Petra De Sutter1,2, Liv Veldeman1, Pascale Kok1, Nathalie Szymczak1, Josiane Van der Elst1 and Marc Dhont1

1 Infertility Centre, University Hospital Gent, Belgium

2 To whom correspondence should be addressed at University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. Email: petra.desutter{at}ugent.be

INTRODUCTION: Pregnancy outcome after IVF has been shown to be worse than after spontaneous conception. There is discussion as to whether this results from the technique itself or the patient characteristics. This study compares pregnancy outcome after IVF and intra-uterine inemination (IUI) in a matched patient group. METHODS: Data were obtained from our IVF and IUI databases (1997–2001). Matching was performed for maternal age, parity and plurality, and 126 IUI pregnancies were compared with 126 IVF pregnancies. Outcome variables were pregnancy duration, birth weight, Caesarean section rates, preterm contraction rates, neonatal intensive care unit admission, Apgar score, blood loss rates and maternal hypertension. RESULTS: None of the analysed parameters was statistically different between the groups. CONCLUSION: This matched case–control study does not show different pregnancy outcomes after IVF and IUI. Since there is no reason to believe that the IUI technique in itself leads to an increased obstetric or neonatal risk, this study suggests that the worse pregnancy outcome after IVF as compared with spontaneous conceptions is due to the specific patient characteristics, rather than to the use of IVF itself.

Key words: intra-uterine insemination/IVF/perinatal outcome/pregnancy


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