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Hum. Reprod. Advance Access originally published online on February 25, 2005
Human Reproduction 2005 20(6):1688-1694; doi:10.1093/humrep/deh817
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities

Myung-Geol Pang1,2,5, Young Ju Kim3, Sang-Hoon Lee2,4 and Chang-Keun Kim1,2

1 Department of Animal Science and Technology, Chung-Ang University, Gyungki-Do 456-756, 2 BET Research Institute, Chung-Ang University, Gyungki-Do 456-756, 3 Department of Obstetrics and Gynaecology, Ewha Woman's University MokDong Hospital, Seoul 158-051 and 4 Department of Obstetric and Gynaecology, Chung-Ang University Hospital, Seoul 100-272, Korea

5 To whom correspondence should be addressed. Email: mgpang{at}cau.ac.kr

BACKGROUND:The high frequency of aneuploidy sperm raises concerns that there may be an increased incidence of aneuploid offspring in ICSI programmes. In order to assess the role that chromosome complement plays in normal and abnormal fertility, detailed molecular cytogenetic studies must be done on sperm samples from men with normal and abnormal fertility. METHODS: To understand more clearly the cytogenetic make-up of sperm from oligoasthenoteratozoospermic (OAT) patients, multi-colour fluorescence in situ hybridization was used to determine numerical chromosome abnormalities. RESULTS: Increased aneuploidy frequencies for chromosomes 13, 18, 21, X and Y were detected in sperm from OAT patients. The frequencies of diploidy also increased. There were no differences in non-disjunction at meiosis I compared to meiosis II. Sperm count inversely correlated with the frequencies of diploidy, aneuploidies for chromosomes 13 and 21 in OAT patients. Twenty-two cycles of ICSI and 18 embryo transfers were performed in 20 couples. Only three cases achieved successful pregnancies. CONCLUSIONS: A higher incidence of meiotic errors and lower sperm counts was found in sperm from OAT patients.

Key words: aneuploidy/FISH/male infertility/meiosis/sperm


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