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Preimplantation genetic diagnosis for an insertional translocation
Department of Cytogenetics and Centre for Preimplantation Genetic Diagnosis, Guy's & St Thomas' NHS Foundation Trust, St Thomas Street, London, SE1 9RT, UK
Email: Paul.Scriven@gstt.sthames.nhs.uk
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Sir,
Melotte et al. (2004)
present two unsuccessful cycles of preimplantation genetic diagnosis (PGD) for a couple where the female partner carries an interchromosomal insertional translocation of part of the long arm of chromosome 2 into the long arm of chromosome 14. The authors present an elegant proof showing that it may be necessary to incorporate up to four probes into