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Hum. Reprod. Advance Access originally published online on May 19, 2005
Human Reproduction 2005 20(7):1751-1756; doi:10.1093/humrep/deh679
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Managing risk associated with cryopreservation

Mathew Tomlinson*

Fertility Unit, Department of Obstetrics and Gynaecology, Queen's Medical Centre, B Floor, East Block, Nottingham, NG7 2UH & Assisted Conception Unit, Birmingham Women's Hospital, Edgbaston, Birmingham, B15 2TG, UK

* CorrespondenceEmail: mathew.tomlinson{at}gmc.nhs.uk

Patients who consent to the frozen storage of sperm or embryos quite rightly expect the storing centre to do everything reasonably possible to keep them in optimum conditions. Both the process of cryopreservation and the cryofacility are loaded with risk, from patient/sample processing, through to the eventual utilization or disposal of specimens. The risk management process should focus on minimizing losses, including staff injury, premature warming of cells and tissues, mistaken identity, and transmission of infection. Early warning and monitoring systems should be in place for quality assurance and to prevent incidents involving cryovessels turning critical. Centres must ensure that every reasonable practical measure that can be put in place is done so, and that resourcing of the service adequately reflects the liability it represents.

Key words: cryopreservation/embryo storage/risk management/sperm storage


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