Hum. Reprod. Advance Access originally published online on May 26, 2005
Human Reproduction 2005 20(9):2409-2413; doi:10.1093/humrep/dei100
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Evaluation of metabolic syndrome frequency and premature carotid atherosclerosis in young women with polycystic ovary syndrome
Departments of 1 Obstetrics and Gynecology, 2 Cardiology and 3 Radiology, Kocaeli University, Faculty of Medicine, Sopal
/Derince 41000 Kocaeli, Turkey
4 To whom correspondence should be addressed. Email: vuralb{at}hotmail.com
BACKGROUND: The aim of this study was to evaluate metabolic syndrome frequency, cardiovascular risk profile and premature carotid artery atherosclerosis in patients with polycystic ovary syndrome (PCOS) especially during early adulthood. METHODS: A case–control study was conducted on 43 young women (18–22 years of age) with PCOS and 43 age-matched volunteer controls. Anthropometrical measurements, hormone levels, lipid and glucose profile were obtained from all subjects. Two different criteria were used to assess metabolic syndrome (MS) frequency. Common carotid artery intima-media thickness (IMT) was measured and stepwise multiple linear regression analysis was used to identify the independent cardiovascular risk factors that predict IMT. RESULTS: MS was diagnosed in 11.6% (n=5) of women with PCOS compared to no cases in the control group (P=0.02). The mean IMT was significantly higher in PCOS subjects (0.746±0.106 mm) compared to controls (0.608±0.105 mm, P<0.001). Among many cardiovascular risk factors evaluated, the diagnosis of PCOS, increased body mass index and decreased sex hormone-binding globulin were significant independent predictors of increased IMT. CONCLUSIONS: These findings indicate that adolescence may be a more appropriate time to intervene for PCOS patients, as many cardiovascular risks are already present during early adulthood. As far as IMT is concerned, mechanisms other than hyperandrogenaemia and obesity might be operating as causative factors.
Key words: cardiovascular/metabolic syndrome/PCOS/risk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. F. Witchel Ontogeny of Polycystic Ovary Syndrome: A Creative Approach J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1576 - 1578. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Cascella, S. Palomba, I. De Sio, F. Manguso, F. Giallauria, B. De Simone, D. Tafuri, G. Lombardi, A. Colao, and F. Orio Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome Hum. Reprod., January 1, 2008; 23(1): 153 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.L. Hendriks, J.C.F. Ket, P.G.A. Hompes, R. Homburg, and C.B. Lambalk Why does ovarian surgery in PCOS help? Insight into the endocrine implications of ovarian surgery for ovulation induction in polycystic ovary syndrome Hum. Reprod. Update, May 1, 2007; 13(3): 249 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ibanez, A. Jaramillo, G. Enriquez, E. Miro, A. Lopez-Bermejo, D. Dunger, and F. de Zegher Polycystic ovaries after precocious pubarche: relation to prenatal growth Hum. Reprod., February 1, 2007; 22(2): 395 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Welt, G. Arason, J. A. Gudmundsson, J. Adams, H. Palsdottir, G. Gudlaugsdottir, G. Ingadottir, and W. F. Crowley Defining Constant Versus Variable Phenotypic Features of Women with Polycystic Ovary Syndrome Using Different Ethnic Groups and Populations J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4361 - 4368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. T. Bloomgarden Third Annual World Congress on the Insulin Resistance Syndrome: Associated conditions. Diabetes Care, September 1, 2006; 29(9): 2165 - 2174. [Full Text] [PDF]
|
|
|
|
|
|
L. Ibanez and F. de Zegher Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women Hum. Reprod. Update, May 1, 2006; 12(3): 243 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Ehrmann, D. R. Liljenquist, K. Kasza, R. Azziz, R. S. Legro, M. N. Ghazzi, and for the PCOS/Troglitazone Study Group Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 48 - 53. [Abstract] [Full Text] [PDF]
|
|