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Hum. Reprod. Advance Access originally published online on September 19, 2005
Human Reproduction 2006 21(1):3-21; doi:10.1093/humrep/dei292
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Published by Oxford University Press 2005 on behalf of the European Society of Human Reproduction and Embryology.

ESHRE PAGE

ESHRE PGD Consortium data collection V: Cycles from January to December 2002 with pregnancy follow-up to October 2003

J.C. Harper1,12, K. Boelaert2, J. Geraedts3, G. Harton4, W.G. Kearns5, C. Moutou6, N. Muntjewerff3, S. Repping7, S. SenGupta1, P.N. Scriven8, J. Traeger-Synodinos9, K. Vesela10, L. Wilton11 and K.D. Sermon2

1 UCL Centre for PGD, Department of Obstetrics and Gynecology, University College London, 86–96 Chenies Mews, London WC1E 6HX, UK, 2 Centre for Medical Genetics, University Hospital and Medical School of the Dutch-speaking Brussels Free University (Vrije Universiteit Brussel, VUB), Laarbeeklaan 101, 1090 Brussels, Belgium, 3 PGD working group Maastricht, Department of Clinical Genetics, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands, 4 Genetics and IVF Institute, 3020 Javier Road, Fairfax Virginia, 22031, USA, 5 Shady Grove Centre for Preimplantation Genetics, 15001 Shady Grove Road, Suite 400, Rockville, Maryland, 20850, USA, 6 Service de la Biologie de la Reproduction, SIHCUS-CMCO, 19, Rue Louis Pasteur, BP120, 67303 Schiltigheim, France, 7 Center for Reproductive Medicine, Academic Medical Center, Fertility Laboratory (A1-229), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 8 Department of Cytogenetics, and Center for Preimplantation Genetic Diagnosis, Guy’s and St Thomas’ NHS Foundation Trust, Guy’s Hospital, St Thomas Street, London SE1 9RT, UK, 9 Laboratory of Medical Genetics, University of Athens, St Sophia’s Children’s Hospital, 11527 Athens, Greece, 10 Sanatorium Repromeda, Vinicni 235, 615 00 Brno, Czech Republic and 11 Melbourne IVF, 320 Victoria Parade, 3002 East Melbourne VIC, Australia

12 To whom correspondence should be addressed: joyce.harper{at}ucl.ac.uk

The fifth report of the ESHRE PGD Consortium is presented (data collection V). For the first time, the cycle data were collected for one calendar year (2002) in the following October, so that data collection was complete for pregnancies and babies. The data were collected using a Filemaker Pro database and divided into referrals, cycles, pregnancies and babies. There are currently 66 active centres registered with the consortium; however, the data presented here were obtained from 43 centres and included 1603 referrals, 2219 cycles, 485 pregnancies and 382 babies born. The cycle data were divided into preimplantation genetic diagnosis (PGD) for inherited disorders (including chromosome abnormalities, sexing for X-linked disease and monogenic disorders), aneuploidy screening (PGS) and the use of PGD for social sexing. Data collection V is compared with the previous cumulative data collection (I–IV), which comprised 4058 PGD/PGS cycles that reached oocyte retrieval.

Key words: aneuploidy screening/preimplantation genetic diagnosis/embryo biopsy/PGS/PGD


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