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Hum. Reprod. Advance Access originally published online on August 22, 2006
Human Reproduction 2006 21(10):2580-2582; doi:10.1093/humrep/del321
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Associate editor’s commentary on ‘Beneficial effect of luteal-phase GnRH agonist administration on embryo implantation after ICSI in both GnRH agonist- and antagonist-treated ovarian stimulation cycles’ by Tesarik et al.

GnRH agonist for luteal support in IVF? Setting the balance between enthusiasm and caution

Cornelis B. Lambalk and Roy Homburg

Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre (VUmc), Amsterdam, the Netherlands

E-mail: cb.lambalk@vumc.nl

Key words: corpus luteum function/embryo developmental potential/GnRH agonist/GnRH antagonist/luteal phase support

The first 150 words of the full text of this article appear below.

GnRH induces LH and FSH secretion by the pituitary gonadotroph cells in an orderly way, which is crucial for the control of gonadal function. Sustained stimulation of the pituitary with GnRH itself or with a GnRH agonist causes desensitization resulting in partial chemical reversible hypophysectomy that has become one of GnRH agonist applications as the cornerstone adjuvant medical treatment for disseminated prostate cancer and as an important tool in medical treatment of other sex steroid-dependent disorders such as leiomyomata and endometriosis.

However, nowadays, the most widely used application is with hormonal treatment protocols for women undergoing IVF. Although the first IVF treatments ever performed were in a natural cycle, it became clear that more success was obtained if more than one oocyte could be retrieved at a time, and thus, ovarian stimulation with gonadotrophins was introduced but with one important disadvantage namely the not infrequent premature luteinization due to the . . . [Full Text of this Article]


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