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Hum. Reprod. Advance Access originally published online on June 21, 2006
Human Reproduction 2006 21(10):2606-2611; doi:10.1093/humrep/del234
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination

Anita Sik Yau Kan1,4, Natalie Caves2, Sylvia Yuen Wai Wong3, Ernest Hung Yu Ng1 and Pak Chung Ho1

1 Department of Obstetrics and Gynaecology 2 Department of Anaesthesiology and 3 Operation Theatre Service, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, People’s Republic of China. E-mail: kansy{at}ha.org.hk

BACKGROUND: This prospective study assessed the role of a 50:50 mixture of nitrous oxide (N2O) and oxygen for pain relief during the termination of first trimester pregnancies by suction evacuation under conscious sedation. METHODS: Ninety women undergoing suction evacuation up to 12 weeks of gestation were randomized by a computer-generated randomization list and allocated using sealed envelopes to receive the N2O/O2 mixture or air during the operation. Pain scores during and after suction evacuation, post-operative side effects and satisfaction level were compared. RESULTS: No statistically significant differences in pain scores, post-operative side effects and satisfaction levels were found between the two groups. CONCLUSION: N2O/O2 did not reduce the pain level during suction evacuation for the first trimester pregnancy termination under conscious sedation.

Key words: N2O/oxygen/pain relief/suction evacuation


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