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Hum. Reprod. Advance Access originally published online on January 23, 2006
Human Reproduction 2006 21(5):1232-1236; doi:10.1093/humrep/dei453
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Results of assisted reproductive technique in men with cystic fibrosis

Dominique Hubert1, Catherine Patrat2, Juliette Guibert3, Nicolas Thiounn4, Thierry Bienvenu5, Géraldine Viot6, Pierre Jouannet2 and Sylvie Epelboin7,8

1 Centre de Ressources et de Compétences pour la Mucoviscidose – Service de Pneumologie, 2 Histologie-Embryologie-Biologie de la Reproduction, 3 Service de Gynécologie-Obstétrique et Médecine de la Reproduction Cochin, 4 Service d’Urologie, 5 Biochimie et Génétique Moléculaire, 6 Génétique Médicale and 7 Service de Gynécologie-Obstétrique et Médecine de la Reproduction Saint Vincent de Paul, Groupe Hospitalier Cochin Saint Vincent de Paul, Assistance Publique Hôpitaux de Paris, Paris, France

8 To whom correspondence should be addressed at: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Saint Vincent de Paul, 82, Avenue Denfert-Rochereau Paris Cedex 14, Paris, France. E-mail: s.epelboin{at}svp.aphp.fr

BACKGROUND: Sterility in men with cystic fibrosis (CF) raises the question of the use of assisted reproductive techniques (ART). A multidisciplinary network including adult CF centre and reproductive medicine units was set up to answer requests for ART. METHODS: This retrospective study included 25 men with CF between 1994 and 2004. Clinical status, semen analysis, CF mutations analysis and artificial insemination by donor (AID) or ICSI after surgical retrieval of sperm were monitored. RESULTS: All CF men had azoospermia. Two chose AID first (one delivery); 23 chose ICSI. Sperm were surgically retrieved in 21 cases, and ICSI was performed in 19. Pregnancies occurred in 12 of these 19 couples (63%) (two ectopic pregnancies, two spontaneous abortions, one termination of pregnancy for polymalformed twins and 11 single deliveries in nine couples). Two couples tried AID after ICSI failed; one had twins. Another adopted a child, and two had a spontaneous pregnancy. After a follow-up of 4.1±2.3 years, two patients died, two underwent lung transplantation and 21 remained stable. CONCLUSION: ART can help men with CF to become a father, but their health status and short survival need careful counselling and multidisciplinary medical care.

Key words: assisted reproductive techniques/cystic fibrosis/ethical issues/ICSI


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