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Human Reproduction 2006 21(6):1643-1644; doi:10.1093/humrep/del129
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Letter to the editor

Expansion of the germline analysis for the INHA gene in Indian women with ovarian failure

H. Dixit1, K.L. Rao1, V. Padmalatha1, M. Kanakavalli1, M. Deenadayal2, N. Gupta3, B.N. Chakravarty3 and L. Singh1,4

1 Centre for Cellular and Molecular Biology, 2 Infertility Institute and Research Centre, Hyderabad, Andhra Pradesh and 3 Institute of Reproductive Medicine, Kolkata, West Bengal, India

4 To whom correspondence should be addressed at: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Andhra Pradesh, India. E-mail: lalji@ccmb.res.in

The first 10% of the full text of this article appears below.

Sir,

Previously we had reported mutational analysis of the mature peptide region of inhibin genes (INHA, INHBA and INHBB) in Indian women with ovarian failure (Dixit et al., 2004Go). This article has reported a significant association of the c.769G>A (p.Ala257Thr) missense variant in INHA gene (inhibin alpha) in Indian women with ovarian failure. Our article demonstrated the presence of this variant in 11.2% cases of premature ovarian failure (POF) and 9.1% cases of primary amenorrhoea (PA) with their complete absence in controls. This published article described a case–control study based on the 80 cases of POF, 33 . . . [Full Text of this Article]


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