Skip Navigation


Hum. Reprod. Advance Access originally published online on February 23, 2006
Human Reproduction 2006 21(7):1787-1790; doi:10.1093/humrep/del049
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/7/1787    most recent
del049v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Berkovitz, A.
Right arrow Articles by Bartoov, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berkovitz, A.
Right arrow Articles by Bartoov, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Does the presence of nuclear vacuoles in human sperm selected for ICSI affect pregnancy outcome?

Arie Berkovitz 1 , Fina Eltes 2 , Adrian Ellenbogen 3 , Sigal Peer 2 , Dov Feldberg 4 and Benjamin Bartoov 2 , 5

1 IVF Unit, Department of Obstetrics and Gynaecology, Sapir Medical Center, Meir Hospital, Kfar Saba 2 Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 3 Department of Obstetrics and Gynaecology, IVF Unit, Hillel-Yaffe Medical Center, Hadera and 4 IVF Unit, Herzliya Medical Center, Herzliya-on-the-Sea, Israel

5 To whom correspondence should be addressed at: Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel. E-mail: bartoob{at}mail.biu.ac.il

BACKGROUND: To verify whether or not microinjection of sperm with a normal nuclear shape but large vacuoles affects IVF–ICSI pregnancy outcome. METHODS: A comparative study testing IVF outcome parameters of IVF–ICSI, based on morphological selection of spermatozoa with normal nuclei against those based on microinjection of sperm with a normal nuclear shape but large vacuoles. An experimental group, including 28 IVF–ICSI cycles, where only embryos obtained from microinjection of spermatozoa with a normal nuclear shape but large vacuoles were transferred, was matched with a control group, including 28 IVF–ICSI cycles, where only embryos obtained from microinjection of spermatozoa with a strictly defined morphologically normal nuclear shape and content were transferred. The main outcome was IVF–ICSI pregnancy rate. RESULTS: The experimental group exhibited a significantly lower pregnancy rate per cycle and significantly higher abortion rate per pregnancy compared to the control group (18 versus 50%, and 80 versus 7%, respectively, P = 0.01). CONCLUSION: Microinjection of vacuolated sperm appears to reduce the pregnancy rate and appears to be associated with early abortion.

Key words: IVF–ICSI/IVF pregnancy outcome/vacuolated spermatozoa


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.