Hum. Reprod. Advance Access originally published online on March 23, 2006
Human Reproduction 2006 21(7):1894-1900; doi:10.1093/humrep/del072
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study
1 To whom correspondence should be addressed at: Department of Gynecology, Cliniques Universitaires St Luc, Université Catholique de Louvain, B-1200 Brussels, Belgium. E-mail: donnez{at}gyne.ucl.ac.be
This research was presented in part at the European Society of Human Reproduction and Embryology 21st Annual Meeting, Copenhagen, Denmark, June 2005.
BACKGROUND: The aim of the study was to investigate whether intranasal (IN) administration of a GnRH agonist could provide luteal support in IVF/ICSI patients. METHODS: Controlled ovarian hyperstimulation (COH) was performed using hMG/FSH and a GnRH antagonist. Patients were then randomly allocated to either 10 000 IU hCG, followed by vaginal administration of micronized progesterone (3x 200 mg/day) (group A), or 200 µg IN buserelin followed by either 100 µg every 2 days (group B), or 100 µg every day (group C), or 100 µg twice a day (group D), or 100 µg three times a day (group E). Luteal support was continued for 15 days. RESULTS: Twenty-three patients were randomized. Groups B and C were discontinued prematurely in view of the short luteal phase. The luteal phase was significantly shorter in groups B, C and D, whereas group E was comparable with group A, 13.5 and 13.0 days, respectively. In the mid-luteal phase, median progesterone levels were significantly lower in groups B, C and D, whereas group E was comparable with group A, 68.9 and 98.0 ng/ml, respectively. Estradiol (E2) was significantly reduced in groups B and D but sustained in group E. In the hCG group, LH levels were undetectable (<0.1 IU/l), whereas LH was detectable and significantly higher in groups C, D and E. Two pregnancies were obtained in the hCG group (two of five), one ectopic and one ongoing. Three pregnancies were obtained in group E, one miscarriage and two ongoing twin pregnancies (three of five). CONCLUSION: IN administration of buserelin may be effective in triggering follicular maturation and providing luteal phase support in patients undergoing assisted reproduction techniques (ART).
Key words: ART/buserelin/GnRH agonist/GnRH antagonist/luteal support
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Ata, K. Yakin, B. Balaban, and B. Urman GnRH agonist protocol administration in the luteal phase in ICSI-ET cycles stimulated with the long GnRH agonistprotocol: a randomized, controlled double blind study Hum. Reprod., March 1, 2008; 23(3): 668 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Lambalk and R. Homburg GnRH agonist for luteal support in IVF? Setting the balance between enthusiasm and caution Hum. Reprod., October 1, 2006; 21(10): 2580 - 2582. [Full Text] [PDF]
|
|