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Hum. Reprod. Advance Access originally published online on April 13, 2006
Human Reproduction 2006 21(8):2110-2113; doi:10.1093/humrep/del113
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Luteinized unruptured follicle syndrome: incidence and recurrence rate in infertile women with unexplained infertility undergoing intrauterine insemination

H. Qublan1,3, Z. Amarin2, M. Nawasreh1, F. Diab1, S. Malkawi1, N. Al-Ahmad1 and M. Balawneh1

1 Department of Obstetrics and Gynaecology, Prince Rashid Hospital, Royal Medical Services, Irbid, Jordan and 2 Department of Obstetrics and Gynaecology, Jordan University of Science and Technology, Irbid, Jordan

3 To whom correspondence should be addressed at: Irbid-Aidoun, P.O. Box 97, Irbid 21166, Jordan. E-mail: hqublan{at}yahoo.com

BACKGROUND: The objective of this study was to determine the incidence and recurrence rate of luteinized unruptured follicle (LUF) syndrome in women with unexplained infertility undergoing intrauterine insemination (IUI). METHODS: A total of 167 women with unexplained infertility who underwent 292 cycles of IUI were enrolled in the study. All patients were treated with clomiphene citrate, 50–150 mg/daily from day 5 to 9 of their menstrual cycle. Ultrasound examination to confirm ovulation was performed on the day of IUI (day 0) and every day thereafter for another 3 days (days 1, 2 and 3). A total of 69 women who failed to conceive in the first cycle and 56 women who failed to conceive in the second cycle underwent second and third cycles, respectively. RESULTS: Of the total 167 patients who underwent first cycle, 42 (25%) had LUF. The incidence of LUF was 56.5% in 69 patients who underwent a second cycle of IUI treatment, of whom 33 patients had LUF in the first cycle with recurrence rate of 78.6%. In 56 patients who underwent 3 consecutive cycles, the incidence of LUF was 58.9% and recurrence rate of 90%. No pregnancies were recorded in patients with LUF during the study period. CONCLUSION: The incidence and recurrence rate of LUF are significantly increased in subsequent cycles of IUI. In these patients, other options of infertility treatment might be justified.

Key words: intrauterine insemination/luteinized unruptured follicle syndrome/pregnancy rate/unexplained infertility


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