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Hum. Reprod. Advance Access originally published online on May 16, 2006
Human Reproduction 2006 21(9):2364-2367; doi:10.1093/humrep/del154
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The type of catheter has no impact on the pregnancy rate after intrauterine insemination: a randomized study

A.-M. Vermeylen1, T. D’Hooghe, S. Debrock, L. Meeuwis, C. Meuleman and C. Spiessens

Department of Obstetrics and Gynecology, University Hospital Leuven, Leuven, Belgium

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium. E-mail: amvermeylen{at}hotmail.com

BACKGROUND: This study was done to test the hypothesis that intrauterine insemination (IUI) using a soft-tip catheter results in a higher live birth rate than IUI using a hard-tip catheter. METHODS: Five hundred and forty patients were randomized into those inseminated with a soft-tip catheter (group 1, n = 267) and those inseminated with a hard-tip catheter (group 2, n = 269). Four patients were excluded. Main outcome measures included pregnancy rate and live birth rate per cycle. RESULTS: Both groups were similar with regard to female age, duration of infertility, ovarian stimulation and sperm quality. No significant differences were observed between group 1 and group 2 regarding clinical pregnancy rate per cycle (20 versus 19%), live birth rate per cycle (15 versus 14%), multiple live birth rate per cycle (4 versus 6%) and multiple live birth per total of live births (5 versus 8%, overall 6%), respectively. CONCLUSION: Our hypothesis that IUI using a soft tip catheter results in a higher live birth rate per cycle than IUI using a hard-tip catheter was not confirmed in this study. Multiple live birth rate after treatment with low-dose gonadotrophins and IUI can be kept low (6%).

Key words: catheter/hard tip/infertility/intrauterine insemination/soft tip


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