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Hum. Reprod. Advance Access originally published online on June 3, 2006
Human Reproduction 2006 21(9):2375-2383; doi:10.1093/humrep/del192
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cumulative pregnancy rates after three cycles of minimal stimulation IVF and results according to subfertility diagnosis: a multicentre cohort study

M.J. Pelinck1,5, N.E.A. Vogel1, A. Hoek1, A.H.M. Simons1, E.G.J.M. Arts1, M.H. Mochtar2, S. Beemsterboer3, M.N. Hondelink4 and M.J. Heineman1

1 Section of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen 2 Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Center 3 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Center, Amsterdam and 4 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Isala Clinics, Location Sophia, Zwolle, The Netherlands

5 To whom correspondence should be addressed at: Section of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Center Groningen, Hanzeplein 1, Groningen 9700 RB, The Netherlands. E-mail: pelinck{at}hotmail.com

BACKGROUND: In minimal stimulation IVF, treatment is aimed at using the single oocyte that spontaneously develops to dominance. To prevent untimely ovulation, a GnRH antagonist is administered in the late follicular phase of the natural cycle together with recombinant FSH for substitution. Owing to the lack of ovarian stimulation, minimal stimulation IVF is a low-risk and patient-friendly treatment. In this study, effectiveness of minimal stimulation IVF was studied. METHODS: In this prospective multicentre cohort study, minimal stimulation IVF was offered to 350 patients. All indications for conventional IVF were included. Main outcome measures were pregnancy rates per cycle and cumulative pregnancy rates after three cycles. RESULTS: A total of 336 patients completed 844 cycles (2.5 per patient). The overall ongoing pregnancy rate per started cycle was 8.3% [95% confidence interval (CI) 6.4–10.2%]. The cumulative ongoing pregnancy rate after up to three cycles was 20.8% (95% CI 16.4–25.3%) per patient. No differences were found according to indication for IVF. CONCLUSIONS: Minimal stimulation IVF seems suitable for all indications studied. Pregnancy rates are encouraging. Owing to the low-risk and patient-friendly nature of this protocol, it seems a feasible treatment option for patients requiring IVF.

Key words: GnRH antagonist/IVF/minimal stimulation/natural cycle/single-embryo transfer


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