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Hum. Reprod. Advance Access originally published online on November 17, 2006
Human Reproduction 2007 22(3):662-668; doi:10.1093/humrep/del430
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Effect of different sites for cryopreserved ovarian tissue implantation in rabbit

Xiao-hui Deng1,4, An-ran Xu1, Lan Chao1, Hong-ling Yu1, Jun-hui Zhen2, Shu Hashimoto3 and Yoshiharu Morimoto3

1 Center for Reproductive Medicine 2 Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China and 3 IVF Namba Clinic, Center for Reproductive Medicine and Infertility, Osaka, Japan

4 To whom correspondence should be addressed at: Center for Reproductive Medicine, Qilu Hospital of Shandong University, Jinan 250012, Shandong, People’s Republic of China. E-mail: dxh{at}sdu.edu.cn

BACKGROUND: Autotransplantation of frozen-thawed ovarian tissue has proven to be an effective method to restore endocrine function and fertility. But it remains to be studied which site and which method is most effective and practical. We therefore implanted small pieces of cryopreserved ovarian tissues into different sites in rabbits to find the optimal position. METHODS: Fifteen New Zealand white female rabbits were randomly divided into three groups. In group 1, fresh ovarian tissues were implanted into the mesometrium and ovarian bursa. In group 2, cryopreserved ovarian tissues were implanted into the mesometrium and ovarian bursa. In group 3, cryopreserved ovarian tissues were implanted into the preserved ovary. RESULTS: There were no significant differences among the three groups as to the proportions of normal and morphologically changed follicles in implanted ovarian tissues. The implanted ovarian tissues in the three groups did not show any evident changes in histology and ultrastructure, and all resumed follicle development and revealed maturescent follicles. CONCLUSIONS: Cryopreservation and implantation of small pieces of ovarian tissues are feasible. Generally, the mesometrium, ovarian bursa and ovary are all available sites for implantation and have similar rates of acceptance, despite some differences in the details of implantation.

Key words: cryopreservation/autologous/implantation/ovary

Submitted on August 5, 2006; resubmitted on September 28, 2006; accepted on October 5, 2006.


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