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Hum. Reprod. Advance Access originally published online on July 29, 2008
Human Reproduction 2008 23(11):2421-2426; doi:10.1093/humrep/den289
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Human chorionic gonadotropin levels in early IVF/ICSI pregnancies are higher in singletons after single embryo transfer compared with singletons after double embryo transfer

I. Delbaere1,4, S. Vansteelandt2, J. Gerris1, P. De Sutter1, D. De Bacquer3 and M. Temmerman1

1 Department of Obstetrics and Gynaecology, Ghent University, De Pintelaan 185 B -9000, Gent, Belgium 2 Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281 S9, B-9000 Gent, Belgium 3 Department of Public Health, Ghent University, De Pintelaan 185, B-9000 Gent, Belgium

4 Correspondence address. E-mail: ilse.delbaere{at}ugent.be

BACKGROUND: The aim of this study is to assess differences in human chorionic gonadotropin (hCG) values between singleton IVF/ICSI pregnancies after elective single (eSET) versus double embryo transfer (DET).

METHODS: This is a unicentre, retrospective, non-randomized study of women with eSET or DET in years 2000–2006, giving birth to a singleton child with a birthweight of at least 500 g (N = 790). These women had between 1 and 6 hCG assessments in our centre. Log hCG values from Days 15 to 35 after oocyte pick-up were compared between eSET and DET patients in a multivariate analysis.

RESULTS: We compared log hCG values in 456 eSET patients with log hCG values in 334 DET patients. Log hCG values were significantly higher after eSET than after DET from Day 15 until Day 35 after oocyte pick-up (P < 0.001).

CONCLUSION: The lower hCG values in early pregnancy are possibly due to a delay in implantation when two embryos are transferred and one of them does not implant, but the exact mechanism is unknown.

Key words: hCG/implantation/SET/DET

Submitted on December 18, 2007; resubmitted on June 10, 2008; accepted on June 12, 2008.


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