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Hum. Reprod. Advance Access originally published online on October 23, 2008
Human Reproduction 2008 23(12):2626-2628; doi:10.1093/humrep/den376
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

What next for preimplantation genetic screening? More randomized controlled trials needed?

S. Mastenbroek1,6, P. Scriven2, M. Twisk1, S. Viville3,4,5, F. Van der Veen1 and S. Repping1

1 Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 2 Center for Preimplantation Genetic Diagnosis, Department of Cytogenetics, Guy's and St Thomas' NHS Foundation Trust, London, UK 3 Service de Biologie de la Reproduction–Syndicat Inter-Hospitalier de la Communauté Urbaine de Strasbourg, Centre Médico-Chirurgical et Obstétrical, Service de Biologie, Schiltigheim, France 4 Department of Developmental Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France 5 Faculté de Médecine, Centre Hospitalier Universitaire, Université Louis Pasteur, Strasbourg, France

6 Correspondence address. Tel: +31-20-5663090; E-mail: s.mastenbroek{at}amc.uva.nl

The recent debate on preimplantation genetic screening (PGS) has raised questions about its routine use in clinical practice. It has been suggested that the most effective way to resolve the debate about the usefulness of PGS is to perform more well-designed and well-executed randomized controlled trials (RCTs). However, in view of the lack of evidence for the effectiveness of PGS and the accumulating evidence for its harmfulness, it is our opinion that it is unethical to perform additional RCTs for the indication advanced maternal age using cleavage stage biopsy.

Key words: PGS/ethics/clinical practice

Submitted on July 8, 2008; resubmitted on August 19, 2008; accepted on September 1, 2008.


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