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Hum. Reprod. Advance Access originally published online on September 4, 2008
Human Reproduction 2008 23(12):2680-2685; doi:10.1093/humrep/den332
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Selection of the optimal day for oocyte retrieval based on the diameter of the dominant follicle in hCG-primed in vitro maturation cycles

Weon-Young Son1, Jin-Tae Chung, Belen Herrero, Nicola Dean, Ezgi Demirtas, Hananel Holzer, Shai Elizur, Ri-Cheng Chian and Seang Lin Tan

McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, QC H3A 1A1, Canada

1 Correspondence address. Fax: +1-514-843-1496. E-mail: weon-young.son{at}muhc.mcgill.ca

BACKGROUND: The efficiency of in vitro maturation (IVM) techniques is suboptimal compared with controlled ovarian stimulation combined with IVF cycles, and studies are needed to identify factors that predispose IVM cycles to success or failure. We compared the outcome of IVM cycles with different dominant follicle (DF) size at oocyte retrieval following hCG priming.

METHODS: IVM was performed in 160 patients with polycystic ovaries (171 cycles). We administered 10 000 IU hCG s.c. 35–38 h before oocyte collection when endometrial thickness reached at least 6 mm. IVM cycles were retrospectively analyzed according to DF diameter as follows; Group 1: DF diameter ≤10 mm, Group 2: between 10 and 14 mm, Group 3: >14 mm.

RESULTS: A positive correlation was observed between DF size and number of in vivo matured oocytes collected (Group 1, 2 and 3 = 6.9, 10.6 and 15.1%, respectively). The rates of IVM, fertilization and embryo development were similar among the sibling immature oocytes collected from the three groups. However, clinical pregnancy rate in Group 2 (40.3%) was higher than Group 3 (17.1%) (P < 0.05). Moreover, implantation rates in Groups 1 (13.6%) and 2 (14.3%) were higher than Group 3 (4.9%) (P < 0.01).

CONCLUSIONS: Our results suggest that oocyte collection in IVM cycles should be performed when the DF is 14 mm diameter or less. Sibling immature oocytes may be affected detrimentally if a DF >14 mm is present at oocyte collection.

Key words: dominant follicle diameter/hCG/human immature oocyte/in vitro maturation

Submitted on May 18, 2008; resubmitted on July 25, 2008; accepted on August 1, 2008.


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