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Hum. Reprod. Advance Access originally published online on January 7, 2008
Human Reproduction 2008 23(3):525-529; doi:10.1093/humrep/dem407
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Association of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2

S.S. Han, J.H. No, Y.T. Jeon, J.W. Kim1, N.H. Park, Y.S. Song, S.B. Kang and H.P. Lee

Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

1Correspondence address. Tel: +82-2-2072-3511; Fax: +82-2-762-3599; E-mail: kjwksh{at}snu.ac.kr

BACKGROUND: Many studies have shown that a polymorphism (G870A) in cyclin D1 (CCND1) is associated with carcinogenesis in a variety of cancers. Our aim was to determine if an association exists between the CCND1 G870A polymorphism and uterine leiomyoma in Korean women.

METHODS: Blood samples of 331 cases and 204 controls aged 47.4 ± 7.6 and 46.8 ± 10.4 years (mean ± SD), respectively, were collected. CCND1 genotyping was determined by PCR and restriction fragment length polymorphism.

RESULTS: Allelic frequencies of cases (A, 0.53; G, 0.47) were not significantly different from those of controls (A, 0.49; G, 0.51) (P = 0.22). After adjustment for menarche age and BMI, multivariate logistic regression analysis showed that the AA genotype was not associated with increased risk for uterine leiomyoma [odds ratio (OR) = 1.38, 95% confidence interval (CI); 0.85–2.26, P = 0.19]. However, in stratification analysis of cases and controls with BMI >25 kg/m2, allelic frequencies of cases (A, 0.56; G, 0.44) were significantly different from controls (A, 0.36; G, 0.64) (P = 0.005), and the AA genotype was associated with increased risk for uterine leiomyoma (OR = 3.61, 95% CI; 1.02–12.73, P = 0.046). Furthermore, the OR for AA compared with combined GG and AG genotypes was 3.16 (95% CI 1.01–9.92, P = 0.048).

CONCLUSIONS: The A allele and AA genotype of CCND1 G870A polymorphism have a significant association with an increased risk of the uterine leiomyoma in obese Korean women.

Key words: cyclin D1 polymorphism/uterine leiomyoma/obesity

Submitted on July 26, 2007; resubmitted on November 24, 2007; accepted on December 4, 2007.


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