Skip Navigation


Hum. Reprod. Advance Access originally published online on February 28, 2008
Human Reproduction 2008 23(5):1207-1213; doi:10.1093/humrep/den007
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
23/5/1207    most recent
den007v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Borghese, B.
Right arrow Articles by Chapron, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borghese, B.
Right arrow Articles by Chapron, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression

Bruno Borghese1,2,3,6, Jean-Daniel Chiche2,3, Déwi Vernerey4,5, Claire Chenot2,3, Olivier Mir2,3, Gérard Bijaoui1,2,3, Catherine Bonaiti-Pellié4,5 and Charles Chapron1,2,3

1 Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Service de Gynécologie–Obstétrique II, CHU Cochin-Saint Vincent de Paul, Paris, France 2 Equipe 21, Institut Cochin, Faculté de Médecine Paris 5, Université Paris Descartes, CNRS (UMR 8104), 24 rue du Faubourg Saint-Jacques, 75014 Paris, France 3 Inserm, U567, Paris, France 4 Inserm, U535, Villejuif, France 5 Université Paris Sud, IFR 69, UMR-S535, Villejuif, France

6 Correspondence address. E-mail: borghese{at}cochin.inserm.fr

BACKGROUND: Matrix metalloproteinases (MMPs) may contribute to endometriosis. We tested whether eight functional polymorphisms of these genes could modify the risk of endometriosis.

METHODS: In this case–control study, 227 endometriosis and 241 controls were genotyped for MMP1 –1607 1G/2G, MMP2 –1575 G/A (MMP2.1), –1306 C/T (MMP2.2), MMP3 –1612 5A/6A, MMP7 –153 C/T (MMP7.1), –181 A/G (MMP7.2), MMP12 –82 A/G and MMP13–77 A/G. Association between MMP genotypes and superficial (SUP), deep infiltrating (DIE) and endometriomas (OMA) was tested for each polymorphism separately, using unconditional logistic regression and then for combined genotypes, using the combination test.

RESULTS: When considering all cases, MMP2 polymorphisms were found to be significant, mainly due to DIE (P = 0.023). A small difference between SUP and controls was found for MMP7.2 (P = 0.032) and MMP12 (P = 0.035), in the absence of correction for multiple testing. Using the combination test, the best association when comparing SUP with controls was obtained for MMP12–MMP13 (P = 0.004) for the combined genotype A/G–A/A (odds ratio = 27.60, 95% confidence interval: 2.80–272.40).

CONCLUSIONS: These data show a potential role for MMP12 –82 A/G and MMP13 –77 A/G combined polymorphisms in superficial endometriosis. As no association was found with deep infiltrating endometriosis, this combination of polymorphisms might protect from a more in-depth penetration of tissues.

Key words: endometriosis/matrix metalloproteinase/polymorphism/combination test/genetics

Submitted on October 2, 2007; resubmitted on November 14, 2007; accepted on November 28, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.