Hum. Reprod. Advance Access originally published online on February 27, 2008
Human Reproduction 2008 23(6):1240-1241; doi:10.1093/humrep/den019
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The human sperm proteome: the potential for new biomarkers of male fertility and a transformation in our understanding of the spermatozoon as a machine
Commentary on the article Identification of proteomic differences in asthenozoospermic sperm samples by Martinez et al.
Reproductive and Developmental Biology, Division of Maternal and Child Health Sciences, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, Scotland
Correspondence address. Tel: +44-1382-740170; Fax: +44-1382-425554; E-mail: c.barratt@dundee.ac.uk
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The comprehensive and systematic identification and quantification of proteins expressed in cells and tissues are providing fascinating insights into the dynamics of cell function in a plethora of areas, for example, cancer—the blood peptidome (Petricoin et al., 2006
). With no physiologically active transcription and translation, spermatozoa are ideal cells to study from a proteomic perspective. As such, proteomics has the potential to transform our understanding of the workings of the mature cell. Such a leap in knowledge is necessary as spermatozoa are very specialized cells that have jettisoned superfluous