Skip Navigation


Hum. Reprod. Advance Access originally published online on February 19, 2008
Human Reproduction 2008 23(7):1560-1566; doi:10.1093/humrep/den033
This Article
Right arrow Full Text
Right arrow Full Text (PDF )
Right arrow All Versions of this Article:
23/7/1560    most recent
den033v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Nekkebroeck, J.
Right arrow Articles by Ponjaert-Kristoffersen, I.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nekkebroeck, J.
Right arrow Articles by Ponjaert-Kristoffersen, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/screening

Julie Nekkebroeck1,3, Maryse Bonduelle2, Sonja Desmyttere2, Wim Van den Broeck1 and Ingrid Ponjaert-Kristoffersen1

1 Department of Developmental and Lifespan Psychology, Vrije Universiteit Brussel, Pleinlaan 2, Brussels 1050, Belgium 2 Centre for Medical Genetics, UZBrussel, Brussels, Belgium

3 Correspondence address. julie.nekkebroeck{at}vub.ac.be

BACKGROUND: diagnostic purposes in preimplantation genetic diagnosis (PGD) or to increase pregnancy rate in preimplantation genetic screening (PGS). The objective of this study is to assess mental and psychomotor developmental outcomes in 2-year-old children born after PGD/PGS, intracytoplasmic sperm injection (ICSI) and natural conception (NC).

METHODS: Two-year-old PGD/PGS (n = 70), ICSI (n = 70) and naturally conceived (n = 70) singleton children were recruited. The participation rate in the NC group was 88.6% and 94.5% in both ART conception groups. The mental and psychomotor development of the children was assessed using the Dutch version of the Bayley Scales of Infant Development. The mothers were questioned about socio-demographic characteristics.

RESULTS: Even after controlling for socio-demographic variables, no differences were found between the three conception groups for the mental and psychomotor developmental outcomes. Moreover, an equal number of PGD/PGS, ICSI and NC children obtained scores within the mildly delayed, the normal and the accelerated performance category of the BSID-II-NL.

CONCLUSIONS: Children conceived after PGD/PGS show similar mental and psychomotor developmental outcomes at age 2 to children conceived after ICSI or naturally.

Key words: PGD/PGS/mental development/psychomotor development/child follow-up

Submitted on October 17, 2007; resubmitted on January 11, 2008; accepted on January 22, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.