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Hum. Reprod. Advance Access originally published online on May 24, 2008
Human Reproduction 2008 23(8):1835-1839; doi:10.1093/humrep/den188
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Body mass index: impact on IVF success appears age-related {dagger}

Megan L. Sneed1, Meike L. Uhler2,4, H. Edward Grotjan3, John J. Rapisarda2, Kevin J. Lederer2 and Angeline N. Beltsos2

1 Department of Obstetrics and Gynecology, Lutheran General Hospital, 1775 Dempster Street, Park Ridge, IL 60068, USA 2 Fertility Center of Illinois, 900 North Kingsbury Street, Suite RW6, Chicago, IL 60610, USA 3 EMD Serono, Inc., One Technology Place, Rockland, MA 02370, USA

4 Correspondence address. Fertility Center of Illinois, 2056 Westings Avenue, Suite 130, Naperville, IL 60563, USA. Fax: +1-630-305-7990; E-mail: meike.uhler{at}integramed.com

BACKGROUND: The objective of this study was to examine the effect of BMI on IVF outcomes.

METHODS: This was a retrospective analysis of all patients undergoing IVF from 1st January 2005 to 1st March 2006 in a large private practice using a single IVF laboratory. The patients underwent standard protocols for controlled ovarian hyperstimulation and embryology parameters. The main outcome measure was clinical pregnancy rate.

RESULTS: A total of 2167 fresh, non-donor IVF cycles were queried, but to minimize bias, only the first treatment cycle for each patient was analyzed (n = 1273). The data were examined by multiple regression models that included BMI and Age as main effects plus a BMI x Age interaction. When examined as a main effect, BMI did not appear to have a major effect on IVF outcome, but there was a significant BMI x Age interaction. At younger ages, a high BMI had a pronounced negative influence on fertility, but this effect diminished as the patient age increased. Clinical pregnancy rates decreased with increasing BMI and increasing Age.

CONCLUSIONS: In younger patients undergoing IVF, BMI has a significant negative impact on fertility that diminishes as patients reach their mid thirties. After Age 36, BMI has a minimal impact on fertility.

Key words: age/fertility/obesity/body mass index/IVF

{dagger} Presented in part at the Annual Meeting of the American Society for Reproductive Medicine, New Orleans, LA, USA, 21–25 October 2006.

Submitted on November 9, 2007; resubmitted on March 20, 2008; accepted on April 8, 2008.


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