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Hum. Reprod. Advance Access originally published online on December 1, 2008
Human Reproduction 2009 24(2):485-490; doi:10.1093/humrep/den430
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene and polycystic ovary syndrome

Kehua Wang1, Leiguang Wang1, Yueran Zhao2,3, Yuhua Shi2, Laicheng Wang3 and Zi-Jiang Chen2,4

1 Shandong Science and Technology Institute of Family Planning, Jinan 250002, People’s Republic of China 2 Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, 324 Jing-5-Wei-7 Road, Jinan 250021, People’s Republic of China 3 Central laboratory, Shandong Provincial Hospital, Jinan 250021, People’s Republic of China

4 Correspondence address.Tel/Fax: 086-531-87068226; E-mail: wangkh0717{at}126.com

BACKGROUND: Ghrelin plays a role in regulating glucose metabolism and energy balance. Polymorphisms in preproghrelin and ghrelin gene could be responsible for obesity, insulin resistance and low ghrelin levels observed in some individuals. The objective of this study was to evaluate the influence of two single-nucleotide polymorphisms (SNPs) of ghrelin gene on the clinical, the hormonal and metabolic features in women with polycystic ovary syndrome (PCOS) in a Chinese population.

METHODS: A large sample of Chinese PCOS (n = 271) women and a control group (n = 296) of healthy women matched for age were studied. Hormone and metabolic profiles were measured and blood samples were collected for genotype and allelic frequency analysis. Non-synonymous SNPs in the coding region (exon 2) of the preproghrelin gene (Arg51Gln (346 G>A) and Leu72Met (408 C>A) were studied using PCR and restriction fragment length polymorphism analysis.

RESULTS: The polymorphism Arg51Gln was not found in the cohorts studied. The distribution of Leu72Met was similar in PCOS group and in healthy controls. There was no significant difference in age, BMI, waist-hip-ratio and levels of FSH, LH, estradiol, testosterone and prolactin between PCOS patients with different genotypes, and the level of plasma glucose and insulin was also similar.

CONCLUSIONS: No association was found between Leu72Met and Arg51Gln polymorphisms in the ghrelin gene and PCOS in Chinese population.

Key words: polycystic ovary syndrome/single nucleotide polymorphism/Ghrelin/gene/glucose metabolism

Submitted on July 22, 2008; resubmitted on October 26, 2008; accepted on November 3, 2008.


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