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Hum. Reprod. Advance Access originally published online on February 3, 2009
Human Reproduction 2009 24(5):1045-1050; doi:10.1093/humrep/dep002
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Frequency and characteristics of endometrial carcinoma and atypical hyperplasia detected on routine infertility investigations in young women: a report of six cases

H. Fujiwara1, S. Ogawa2, M. Motoyama2, Y. Takei1, S. Machida1, A. Taneichi1, M. Ohwada1 and M. Suzuki1,3

1 Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke city, Tochigi 329-0498, Japan 2 Institute for Tochigi Central Clinic, 3154, Yakushiji, Shimotsuke city, Tochigi 329-0498, Japan

3 Correspondence address. E-mail: jichiobgyn{at}hotmail.co.jp

Infertility patients are known to be at increased risk of endometrial carcinoma (EC) and atypical hyperplasia (AH). However, the incidence and clinical features of EC and AH in these patients remain to be clarified. In this study, we examined the rate at which a routine infertility workup revealed EC/AH and investigated the clinicopathological features of EC/AH detected in this way. Among patients diagnosed with EC or AH at the Jichi Medical University Hospital between the 10-year period from 1997 to 2006, six patients were referred from Tochigi Central Clinic, a specialized infertility facility. We report the clinicopathological features of these patients and calculate the incidence of EC/AH in patients who underwent infertility investigations at Tochigi Central Clinic. All six patients were younger than 40 and had early stage disease (final diagnosis: EC stage IA: 3, EC stage IB: 1, AH: 2). A total of 19 826 patients underwent routine infertility investigations at Tochigi Central Clinic during the same period. The incidence of EC/AH detected from these investigations was 0.03% (6/19 826) and that of EC was 0.02% (4/19 826): 5–10 times higher than the overall incidence in Japanese women of the same age. Routine infertility investigations may provide an opportunity to examine the corpus uteri of young women in whom examination is otherwise limited, contributing to the early detection of EC/AH.

Key words: endometrial carcinoma/routine infertility investigations/diagnosis/overall incidence

Submitted on October 1, 2008; resubmitted on December 19, 2008; accepted on January 2, 2009.


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