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Hum. Reprod. Advance Access originally published online on March 3, 2009
Human Reproduction 2009 24(6):1242-1246; doi:10.1093/humrep/dep025
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Possible mechanisms of peritoneal tissue-oxygen tension changes during CO2-pneumoperitoneum: the role of design, methodology and animal models

Editorial commentary on the articles ‘Peritoneal tissue-oxygen tension during a carbon dioxide pneumoperitoneum in a mouse laparoscopic model with controlled respiratory support’ by Bourdel et al. (2007) and ‘Effects of supplemental perioperative oxygen on post-operative abdominal wound adhesions in a mouse laparotomy model with controlled respiratory support’ by Matsuzaki et al. (2007)

Ospan A. Mynbaev1,4 and Roberta Corona2,3

1 Moscow State University of Medicine and Dentistry, Delegatskaya str. 20/1 127473, Moscow, Russian Federation 2 Katholieke Universiteit Leuven (KULeuven) Leuven, Belgium 3 University of Cagliari, Cagliari, Italy

4 Correspondence address. Tel: +7-7252470137; Fax: +7-7252530906; E-mail: ospanmynbaev@hotmail.com

The first 150 words of the full text of this article appear below.


   Animal models and design of experimental studies
 
Recently, Bourdel et al. (2007)Go and Matsuzaki et al. (2007)Go published well-documented articles covering the fundamental aspects of laparoscopy. In order to comment on the study design and on the methodology of studies using mouse ventilation models (VMs), we have carefully studied the review by Bide et al. (1997)Go concerning minute volume (MV) and body weight (BW) relationships since analogous suggestions with reference to respiratory parameters (RPs) and their impact on study results were pointed out in the article of Bourdel et al. (2007)Go.

There is a very large variability in ventilation parameters (VPs) between animal models and between laboratories as well as between anesthetized and non-anesthetized animals. Therefore, Bide et al. (1997)Go analyzed large numbers of studies to provide sufficient statistical data to reduce the effects of biological variability on VPs. Subsequently, we compared these incorporated values of RPs from physiological studies (Bide et al., 1997Go; . . . [Full Text of this Article]

Debates concerning CO2-pneumoperitoneum-induced adhesion formation

   Mechanisms of a tissue-oxygen tension on AF
 

   Conclusions
 

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