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Hum. Reprod. Advance Access originally published online on April 21, 2009
Human Reproduction 2009 24(7):1765; doi:10.1093/humrep/dep095
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Letters to the editor

ART and major structural birth defects in the United States

Alfred A. Rimm1, Alyce C. Katayama2,4 and K. Paul Katayama3

1 School of Medicine, Case Western University, Cleveland, OH, USA 2 Quarles & Brady LLP,
411 East Wisconsin Avenue,
Milwaukee WI 53202, USA 3 Advanced Institute of Fertility, Milwaukee, WI, USA

4 Correspondence address. E-mail: alyce.katayama@quarles.com

The first 10% of the full text of this article appears below.

Sir,

We read with interest the study by Reefhuis et al. (2009)Go showing that assisted reproductive technology (ART) treatment is a risk for structural birth defects. The authors recognize that this risk may be over-stated because underlying subfertility may in itself be an important risk factor for such defects. In our meta-analysis of 19 studies (Rimm et al., 2004Go), where we found an overall risk . . . [Full Text of this Article]


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