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Hum. Reprod. Advance Access originally published online on May 21, 2009
Human Reproduction 2009 24(8):2045-2047; doi:10.1093/humrep/dep188
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Letters to the editor

The importance of good practice in preimplantation genetic screening: critical viewpoints

Carmen Rubio1,8, Carles Giménez2, Esther Fernández3, Xavi Vendrell4, Esther Velilla5,6, Mónica Parriego7, Lorena Rodrigo1 for Spanish Interest Group in Preimplantation Genetics, Spanish Society for the study of the biology of reproduction (ASEBIR)

1 PGD Unit, Instituto Valenciano de Infertilidad IVI-Valencia, Plaza Policía Local No. 3, 46015 Valencia, Spain 2 Reprogenetics Spain, Tuset, 23, 6è 1a., 08006 Barcelona, Spain 3 Geniality Diagnóstico Genético, S.L. C/Santiago Grisolía 2, 28760 Tres Cantos, Madrid, Spain 4 Reproductive Genetics Unit, Sistemas Genómicos S.L., Ronda G. Marconi 6, 46980 Paterna, Valencia, Spain 5 Center for Embryo Medicine, C/Medea 4, 3ero D ‘Edificio ECU’, 28037 Madrid, Spain 6 C/Trias i Pujol no 5, 08034 Barcelona, Spain 7 Servei de Medicina de la Reproducció, Institut Universitari Dexeus, Avda. Carles III, 71-75, 08028 Barcelona, Spain

8 Correspondence address. Tel: + 96-3050900; Fax: + 96-3050999; E-mail: c.rubio@ivi.es

The first 10% of the full text of this article appears below.

Sir,

We read with great interest the recent debate entitled ‘What's next for preimplantation genetic screening (PGS)?’ published in your journal. Most authors concluded that the selection of chromosomally normal embryos for a selected panel of chromosomes does not improve ongoing pregnancy rates per cycle in advanced maternal age (AMA), implantation failure (IF) or ‘good prognosis’ patients undergoing IVF. This is an important message for those practicing reproductive medicine, since we may be over-manipulating the embryos in the IVF laboratories without scientific basis, and therefore increasing the total costs of an IVF cycle without sense. Thus, a critical analysis of the accumulated experience deserves comment, which is the specific objective of this letter.

Regarding AMA patients, four randomized controlled trials (RCTs) have been published so far. In the first of them Staessen et al. (2004)Go reported high . . . [Full Text of this Article]


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