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Human Reproduction, Vol. 3, No. 8, pp. 927-934, 1988
© 1988 European Society of Human Reproduction and Embryology

research-article

Expression of a secretory product by microvillous and ciliated cells of the human endometrial epithelium in vivo and in vitro

S. Campbell, M.W. Seif1, J.D. Aplin1,4, S.J. Richmond, P. Haynes2 and T.D. Allen3

Department of Medical Microbiology, University of Manchester Stopford Building, Oxford Road, Manchester, M13 9PT 1Department of Obstetrics and Gynaecology, University of Manchester at St Mary's Hospital Whitworth Park, Manchester, M13 0JH 2University Department of Obstetrics and Gynaecology, University Hospital of South Manchester West Didsbury, Manchester, M20 8LE 3Department of Ultrastructure, Paterson Laboratories, Christie Hospital and Holt Radium Institute Wilmslow Road, Manchester, M20 9BX, UK

Correspondence: 4To whom correspondence should be addressed

A monoclonal antibody which identifies a component of post-ovulatory endometrial secretions is now shown to be expressed within the cytoplasm and on the cell surface of both microvillous and ciliated epithelial cells. A glandular explantatlon model was developed in order to study the ‘carry over’ of this secretion to the regenerative phase endometriwn. A loss of cytoplasmic antigen was observed in vitro. However, it was retained on the cell surface in a fashion consistent with its expression at the time of explantation. Mosaicism of expression of this secretory component occurs throughout the secretory-phase and is particularly pronounced at the time of transition from proliferative to secretory phase. It is conduded that both ciliated and microvillous epithelial cells produce a post-ovulatory secretory component which may be retained on the cell surface in the absence of hormonal stimulation.

Key words: endometrial secretions/epithelial cells/cilia


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 Mol Hum ReprodHome page
S. Campbell, J. Larsen, M.W. Seif, T.D Allen, F. Knox, C.J.P. Jones, and J.D. Aplin
Mosaic characteristics of human endometrial epithelium in vitro: analysis of secretory markers and cell surface ultrastructure
Mol. Hum. Reprod., January 1, 2000; 6(1): 41 - 49.
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