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Human Reproduction, Vol. 4, No. 6, pp. 653-657, 1989
© 1989 European Society of Human Reproduction and Embryology

other

Effects of anti-sperm anti–bodies on human sperm ultrastructure and function

R.A. Bronson1, G.W. Cooper and D.M. Phillips2

2Population Council, Center for Biomedical Research New York, NY, USA Laboratory of Human Reproduction, North Shore University Hospital—Cornell University Medical College Manhasset

Correspondence: 1To whom correspondence should be addressed at: Division of Reproductive Endocrinology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794–8091, USA

The ultrastructural appearance of a highly motile population of spermatozoa from a fertile donor was evaluated following antibody labeling with each of several sperm head-directed anti-sperm antibodies (ASAs) and subsequent incubation in a capacitating medium in vitro. Acrosomes were classified into categories which are believed to represent stages in the acrosome reaction. Quantitative analysis revealed no difference in acrosomal morphology of antibody-labeled sperm between treatment groups despite a varying degree of enhancement or inhibition of sperm egg-penetrating ability. We conclude that ASAs affect gamete interaction through mechanisms other than an alteration in the acrosome reaction.

Key words: anti-sperm antibodies/acrosomal reaction/oolemma


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 Mol Hum ReprodHome page
C. Bohring, E. Krause, B. Habermann, and W. Krause
Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease
Mol. Hum. Reprod., February 1, 2001; 7(2): 113 - 118.
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