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Human Reproduction, Vol. 7, No. 10, pp. 1347-1352, 1992
© 1992 European Society of Human Reproduction and Embryology

other

Effects of growth hormone administration in addition to gonadotrophins in normally ovulating women and polycystic ovary syndrome (PCO) patients

A. Volpe, P.G. Artini2, A. Barreca3, F. Minuto4, G. Coukos2 and A.R. Genazzani1,2

Department of Obstetrics and Gynaecology, University of Cagliari Via Del Pozzo, 71 41100 Modena 2Department of Obstetrics and Gynaecology, University of Modena Via Del Pozzo, 71 41100 Modena 3Chair of Endocrinology, University of Genoa Via Del Pozzo, 71 41100 Modena 4Chair of Endocrinological Physiopathology, University of Genoa Italy

Correspondence: 1To whom correspondence should be addressed

Follicular fluid sex-steroids, insulin-like growth factor-I (IGF-1), IGF-I binding protein (IGF-I-BP) and epidermal growth factor were investigated in patients with polycystic ovaries and normally ovulating women, following ovulation induction with gonadotrophins or growth hormone plus gonadotrophins. Growth hormone supplementation enhanced the ovarian response to gonadotrophins, and significantly increased follicular fluid IGF-I in both groups, without affecting follicular fluid epidermal growth factor; growth hormone supplementation significantly decreased follicular fluid androstenedione in both groups.

Key words: follicular fluid/growth factors/IVF/ET/PCOD/superovulation


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