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Human Reproduction, Vol. 7, No. 5, pp. 718-722, 1992
© 1992 European Society of Human Reproduction and Embryology

other

Intravenous immunoglobulin treatment of women with multiple miscarriages

O.B. Christiansen1, O. Mathiesen2, J.G. Lauritsen2 and N. Grunnet

Department of Clinical Immunology Aalborg Hospital PO Box 561, DK 9100, Aalborg, Denmark 2Department of Obstetrics and Gynaecology, Aalborg Hospital PO Box 561, DK 9100, Aalborg, Denmark

Correspondence: 1To whom correspondence should be addressed

Eleven women who had previously experienced four to eight unexplained fetal losses (median 6.0 fetal losses/woman) were treated in their next pregnancy with individualized doses of pooled intravenous immunoglobulins. Nine women (82%) delivered healthy infants subsequent to the treatment. Prior to treatment, the pregnant patients had a significantly (P < 0.05) increased median level of complement C3 neodeterminants in the blood compared with a group of 33 normal first trimester pregnant women. This may be a sign of increased turnover of complement in these women.

Key words: abortion/immunoglobulin/recurrent abortion


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