Human Reproduction, Vol. 7, No. 8, pp. 1173-1175, 1992
© 1992 European Society of Human Reproduction and Embryology
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Embryo reduction in multifetal pregnancies using saline injection: comparison between the transvaginal and the transabdominal approach
In Vitro Fertilization Unit, Tel Aviv Sourasky Medical Centre, Serlin Maternity Hospital, Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel
Correspondence: 1To whom correspondence should be addressed
A total of 30 patients with multifetal pregnancies, all resulting from treatment with superovulatory agents or assisted reproductive techniques, underwent embryo reduction. All patients had three or more fetuses (one sextuplet, two quintuplets, seven quadruplets and 20 triplets). The procedure was carried out using intra-embryonal injection of 0.9% sodium chloride solution. Embryo reduction was carried out via the transabdominal approach in 10 patients, performed at 1112 weeks of gestation, and via the transvaginal route in 20 other patients, at 810 weeks of gestation. In the trans-abdominal group, one patient aborted following repeated attempts at embryo reduction while the other nine gave birth to healthy newborns (eight twins and one triplet). In the transvaginal group, four pregnancies are currently ongoing (all beyond 28 weeks of gestation), 14 pregnancies resulted in a delivery of at least one live newborn (13 twins and one singleton), one patient had a late abortion at 24 weeks' gestation and another was delivered at 27 weeks' gestation due to severe pre-eclampsia. Transvaginal ultrasound-guided needle procedures are commonly practised in most in-vitro fertilization units. The employment of this route for embryo reduction, performed at an earlier gestational age and with the use of a non-toxic substance such as 0.9% saline solution, is advocated.
Key words: embryonal reduction/multiple pregnancy/ovulation induction
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