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Hum. Reprod. Advance Access published online on January 29, 2004
Human Reproduction, doi:10.1093/humrep/deh110
© 2004 by European Society of Human Reproduction and Embryology
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Received January 20, 2004

Debate

Assessment of ovarian reserve. Is there still a role for ovarian biopsy?

Fady I. Sharara 1* and Richard T. Scott 2

1 Virginia Center for Reproductive Medicine, Reston, VA, USA; George Washington University, Washington, DC, USA; 11150 Sunset Hills Road, Suite 100, Reston, VA 20190, USA
2 Reproductive Medicine Associates of New Jersey, Morristown, NJ, USA

* To whom correspondence should be addressed. E-mail: RScott{at}rmanj.com.


  Abstract

Multiple endocrine, ultrasound-based and dynamic tests have been proposed for the assessment of ovarian reserve. Lately, ovarian biopsy has been proposed as a more representative functional test of ovarian reserve, and has been recommended as an early step in the investigation of infertility. Central to this hypothesis is the idea that a random biopsy of the ovarian cortex is reflective of the actual ovarian follicular pool. Recent studies have shown a wide variation in the number and distribution of ovarian follicles even from the same ovary and in the same patient. Coupled with the invasiveness of performing the biopsy and the risk of adhesion formation, we believe that there should not be a role for ovarian biopsy in ovarian reserve testing.

Key words: Key words: ovarian biopsy/ovarian reserve testing


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