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Hum. Reprod. Advance Access published online on January 29, 2004
Human Reproduction, doi:10.1093/humrep/deh118
© 2004 by European Society of Human Reproduction and Embryology
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Received July 16, 2003
Revised September 9, 2003
Accepted November 4, 2003

Debate

Assessment of ovarian reserve

Amir Lass 1*

1 Serono Ltd, Bedfont Cross, Stanwell Road, Middlesex TW14 8NX, UK

* To whom correspondence should be addressed. E-mail: amir.lass{at}serono.com.


  Abstract

Ovarian reserve depends on the number of primordial follicles in the ovarian cortex. It was suggested that determining the follicular density directly by obtaining ovarian biopsy might be more accurate than current indirect biochemical and ultrasonic tests, especially for women in the later stage of their reproductive life. It might also be important and beneficial for young patients having chemotherapy for malignant disease in whom the ovarian tissue should be considered for reimplantation after recovery. The advantages and pitfalls of obtaining ovarian biopsy in these cases are discussed in light of new emerging data on the natural distribution of primordial follicles in the human ovary and its implications.

Key words: Key words: cancer/ovarian biopsy/ovarian reserve/primordial follicles


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